Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (1): 31-35.

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Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress

Xiaohui Zhang, Zhaohui Feng, Chunhua Li, Yuping Zheng   

  1. Department of Ophthalmology, Second Affiliated Hospital of Xi’an Jiaotong University Medical College, Xi’an 710004, Shaanxi Province, China
  • Received:2011-08-27 Revised:2011-11-24 Online:2012-01-05 Published:2012-01-05
  • Contact: Zhaohui Feng, Doctor, Professor, Department of Ophthalmology, Second Affiliated Hospital of Xi’an Jiaotong University Medical College, Xi’an 710004, Shaanxi Province, China fzhwyh@126.com
  • About author:Xiaohui Zhang☆, Studying for doctorate, Attending physician, Department of Ophthalmology, Second Affiliated Hospital of Xi’an Jiaotong University Medical College, Xi’an 710004, Shaanxi Province, China

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Abstract:

In the present study, retinal Müller cells were cultured in vitro and treated with hydrogen peroxide (oxidative stressor) and cobalt chloride (hypoxic injury). Following 24 hours of culture, compensatory hypertrophy was observed and cellular apoptosis increased. Hypoxia enhanced the migration ability of retinal Müller cells and induced the expression of α-smooth muscle actin. Oxidative stress altered the morphology of Müller cells when compared with hypoxia treatment.

Key words: retina, Müller cells, hypoxia, oxidative stress, migration, glutamine synthetase, α-smooth muscle actin, neural regeneration