Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (8): 1453-1459.doi: 10.4103/1673-5374.303033

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Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage

Liu-Lin Xiong1, 2, #, Jie Chen1, #, Ruo-Lan Du3, Jia Liu3, Yan-Jun Chen4, Mohammed Al Hawwas2, Xin-Fu Zhou2, Ting-Hua Wang3, 4, Si-Jin Yang1, *, Xue Bai1, *   

  1. 1National Traditional Chinese Medicine Clinical Research Base and Western Medicine Translational Medicine Research Center, Department of Cardiovascular Disease, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan Province, China; 2Cinical and Health Sciences, University of South Australia, Adelaide, Australia; 3Animal Zoology Department, Institute of Neuroscience, Kunming Medical University, Kunming, Yunnan Province, China; 4Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Xue Bai, MS, XueBai159263487@163.com; Si-Jin Yang, MS, ysjimn@sina.com.
  • Supported by:
     This study was supported by the National Natural Science Foundation of China, No. 82001604 (to LLX); the Joint Subject of Southwest Medical University and Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University of China, No. 2018XYLH-004 (to LLX); the National Construction Project of Regional Chinese Medicine Treatment Centre of China, No. 2018205 (to XB); the National Construction Project of the Second Clinical Research Base of Chinese Medicine of China, No. 2018131 (to XB). 

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Abstract: Brain-derived neurotrophic factor (BDNF) regulates many neurological functions and plays a vital role during the recovery from central nervous system injuries. However, the changes in BDNF expression and associated factors following hypoxia-ischemia induced neonatal brain damage, and the significance of these changes are not fully understood. In the present study, a rat model of hypoxic-ischemic brain damage was established through the occlusion of the right common carotid artery, followed by 2 hours in a hypoxic-ischemic environment. Rats with hypoxic-ischemic brain damage presented deficits in both sensory and motor functions, and obvious pathological changes could be detected in brain tissues. The mRNA expression levels of BDNF and its processing enzymes and receptors (Furin, matrix metallopeptidase 9, tissue-type plasminogen activator, tyrosine Kinase receptor B, plasminogen activator inhibitor-1, and Sortilin) were upregulated in the ipsilateral hippocampus and cerebral cortex 6 hours after injury; however, the expression levels of these mRNAs were found to be downregulated in the contralateral hippocampus and cerebral cortex. These findings suggest that BDNF and its processing enzymes and receptors may play important roles in the pathogenesis and recovery from neonatal hypoxic-ischemic brain damage. This study was approved by the Animal Ethics Committee of the University of South Australia (approval No. U12-18) on July 30, 2018. 

Key words: brain injury, brain-derived neurotrophic factor, enzyme, hypoxia-ischemia, receptors, recovery, repair