Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (1): 46-53.

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Transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury

Jindou Jiang1, Xingyao Bu2, Meng Liu2, Peixun Cheng2   

  1. 1 Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
    2 Department of Neurosurgery, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China
  • Received:2011-09-06 Revised:2011-12-19 Online:2012-01-05 Published:2012-01-05
  • Contact: Xingyao Bu, Doctor, Chief physician, Department of Neurosurgery, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China buxingyao@126.com
  • About author:Jindou Jiang☆, Doctor, Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China

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Abstract:

Results from the present study demonstrated that transplantation of autologous bone marrow-derived mesenchymal stem cells into the lesion site in rat brain significantly ameliorated brain tissue pathological changes and brain edema, attenuated glial cell proliferation, and increased brain-derived neurotrophic factor expression. In addition, the number of cells double-labeled for 5-bromodeoxyuridine/glial fibrillary acidic protein and cells expressing nestin increased. Finally, blood vessels were newly generated, and the rats exhibited improved motor and cognitive functions. These results suggested that transplantation of autologous bone marrow-derived mesenchymal stem cells promoted brain remodeling and improved neurological functions following traumatic brain injury.

Key words: angiogenesis, neurogenesis, neurotrophic factors, bone marrow-derived mesenchymal stem cells, traumatic brain injury, stem cell transplantation, neural regeneration