Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (20): 1872-1880.doi: 10.3969/j.issn.1673-5374.2013.20.006

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Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?

Jing Ge1, 2, Jun Wang2, Dan Xue3, Zhengsheng Zhu4, Zhenyu Chen3, Xiaoqiu Li2, Dongfeng Su5, Juan Du1   

  1. 1 Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
    2 The General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China
    3 Department of Gynecology and Obstetrics, People’s Liberation Army No. 202 Hosiptal, Shenyang 110003, Liaoning Province, China
    4 Dantu District Sanitary Supervision Institute, Zhenjiang 212001, Jiangsu Provicne, China
    5 Department of Neurology, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China
  • Received:2013-04-05 Revised:2013-06-06 Online:2013-07-15 Published:2013-07-15
  • Contact: Juan Du, Doctor’s supervisor, Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning Province, China, jingzicat@sina.com.
  • About author:Jing Ge, Ph.D., Associate chief physician. Jing Ge and Jun Wang contributed equally to this article.
  • Supported by:

    全军医学科技研究“十二五"面上项目（CWS11J003）

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Abstract:

Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as hyper-tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein ex-pressions were upregulated in the rat hippocampus. These findings indicate that increased expres-sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats.

Key words: neural regeneration, preeclampsia, eclampsia, excitatory neurotransmitter, neurotoxicity, hyper-lipidemia, hypertension, pregnancy, lipoprotein-associated phospholipase A2, metabotropic gluta-mate receptor 1, grants-supported paper, neuroregeneration