Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (27): 2566-2572.doi: 10.3969/j.issn.1673-5374.2013.27.008

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Low-frequency repetitive transcranial magnetic simulation prevents chronic epileptic seizure

Yinxu Wang, Xiaoming Wang, Sha Ke, Juan Tan, Litian Hu, Yaodan Zhang, Wenjuan Cui   

  1. Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
  • Received:2013-05-08 Revised:2013-08-01 Online:2013-09-25 Published:2013-09-25
  • Contact: Xiaoming Wang, Master, Professor, Master’s supervisor, Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China, wangxm238@163.com.
  • About author:Yinxu Wang, Master, Researcher.
  • Supported by:

    This study was supported by the Key Project of Sichuan Provincial Education Department, No. (2010) 597.

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Abstract:

Although low-frequency repetitive transcranial magnetic simulation can potentially treat epilepsy, its underlying mechanism remains unclear. This study investigated the influence of low-frequency re-petitive transcranial magnetic simulation on changes in several nonlinear dynamic electroenceph-alographic parameters in rats with chronic epilepsy and explored the mechanism underlying repeti-tive transcranial magnetic simulation-induced antiepileptic effects. An epilepsy model was estab-lished using lithium-pilocarpine intraperitoneal injection into adult Sprague-Dawley rats, which were then treated with repetitive transcranial magnetic simulation for 7 consecutive days. Nonlinear elec-electroencephalographic parameters were obtained from the rats at 7, 14, and 28 days post-stimulation. Results showed significantly lower mean correlation-dimension and Kolmogo-rov-entropy values for stimulated rats than for non-stimulated rats. At 28 days, the complexity and point-wise correlation dimensional values were lower in stimulated rats. Low-frequency repetitive transcranial magnetic simulation has suppressive effects on electrical activity in epileptic rats, thus explaining its effectiveness in treating epilepsy.

Key words: neural regeneration, repetitive transcranial magnetic stimulation, electroencephalogram, nonlinear analysis, nonlinear parameters, epilepsy, epileptic seizure, epileptic discharge, grant-supported paper, neuroregeneration