Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (32): 2991-3002.doi: 10.3969/j.issn.1673-5374.2013.32.002

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Orofacial inflammatory pain affects the expression of MT1 and NADPH-d in rat caudal spinal trigeminal nucleus and trigeminal ganglion

Fang Huang, Hongwen He, Wenguo Fan, Yongliang Liu, Hongyu Zhou, Bin Cheng   

  1. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, Guangdong Province, China
  • Received:2012-06-20 Revised:2013-09-11 Online:2013-11-15 Published:2013-11-15
  • Contact: Bin Cheng, Ph.D., Professor, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, Guangdong Province, China, chengbin@mail.sysu.edu.cn.
  • About author:Fang Huang, Ph.D., Associate chief physician.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81271166, 81371107; the Natural Science Foundation of Guangdong Province in China, No. 10451008901006145.

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Abstract:

Very little is known about the role of melatonin in the trigeminal system, including the function of melatonin receptor 1. In the present study, adult rats were injected with formaldehyde into the right vibrissae pad to establish a model of orofacial inflammatory pain. The distribution of melatonin re-ceptor 1 and nicotinamide adenine dinucleotide phosphate diaphorase in the caudal spinal trigem-inal nucleus and trigeminal ganglion was determined with immunohistochemistry and histochemistry. The results show that there are significant differences in melatonin receptor 1 expression and nicotinamide adenine dinucleotide phosphate diaphorase expression in the trigeminal ganglia and caudal spinal nucleus during the early stage of orofacial inflammatory pain. Our findings suggest that when melatonin receptor 1 expression in the caudal spinal nucleus is significantly reduced, melatonin’s regulatory effect on pain is attenuated.

Key words: neural regeneration, pain, melatonin, nitric oxide, maxillofacial pain, caudal spinal trigeminal nucleus, trigeminal ganglia, mesencephalic trigeminal nucleus, melatonin receptor 1, nicotinamide adenine dinucleotide phosphate diaphorase, grants-supported paper, neuroregeneration