Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (32): 2529-2535.

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Ultrasound guided neural stem cell transplantation through the lateral ventricle for treatment of cerebral palsy in children

Sheng He, Zuo Luan, Suqing Qu, Xuan Qiu, Daqing Xin, Wenkai Jia, Yanhua Shen, Zehui Yu,Tao Xu   

  1. Department of Ultrasonography, Navy General Hospital of Chinese PLA, Beijing 100048, China
  • Received:2012-06-11 Revised:2012-09-10 Online:2012-11-15 Published:2012-11-15
  • Contact: Sheng He, Department of Ultrasonography, Navy General Hospital of Chinese PLA, Beijing 100048, China shenghecn2008292@sina.com
  • About author:Sheng He☆, M.D., Chief physician, Department of Ultrasonography, Navy General Hospital of Chinese PLA, Beijing 100048, China

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Abstract:

A total of 24 children with cerebral palsy were enrolled in this study and underwent ultrasound guided transplantation of neural stem cells through the lateral ventricle. Neural stem cells (3.8 × 106–7.3 × 107) were injected into the lateral ventricles. Mild injury of lateral ventricular blood vessels occurred in only two cases (8.3%). Seven cases (29.2%) experienced a fever. Clinical manifestations were improved to varying degrees in eight cases (28.0%) within 3 months after transplantation. Patient condition did not worsen, and no patient experienced severe adverse reactions.

Key words: cerebral palsy in children, puncture of the lateral ventricle, neural stem cells, transplantation, blood vessel injury, ultrasonography, neural regeneration