中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (5): 967-971.doi: 10.4103/1673-5374.297059

• 综述:颅神经损伤修复保护与再生 • 上一篇    下一篇

青光眼治疗的新解决方案:是否可以考虑使用牛磺酸?

  

  • 出版日期:2021-05-15 发布日期:2020-12-29

New solutions for old challenges in glaucoma treatment: is taurine an option to consider?

Igor Iezhitsa1, 2, *, Renu Agarwal1   

  1. 1 School of Medicine, International Medical University, Kuala Lumpur, Malaysia;  2 Volgograd State Medical University, Research Centre for Innovative Medicines, Volgograd, Russian Federation
  • Online:2021-05-15 Published:2020-12-29
  • Contact: Igor Iezhitsa, PhD, igoriezhitsa@imu.edu.my or iezhitsa@yandex.ru.
  • Supported by:
    This work was financially supported by the Institut Pengurusan Penyelidikan (RMI), Universiti Teknologi MARA, Malaysia, under grants 600-IRMI/MyRA 5/3/BESTARI (004/2017) and 600-IRMI/MyRA 5/3/BESTARI (006/2017).

摘要: https://orcid.org/0000-0002-2852-8486 (Igor Iezhitsa) 

Abstract: Glaucoma is a range of progressive optic neuropathies characterized by progressive retinal ganglion cell loss and visual field defects. It is recognized as a leading cause of irreversible blindness affecting more than 70 million people worldwide. Currently, reduction of intraocular pressure, a widely recognized risk factor for glaucoma development, is the only pharmacological strategy for slowing down retinal ganglion cell loss and disease progression. However, retinal ganglion cell death and visual field loss have been observed in normotensive glaucoma, suggesting that the disease process is partially independent of intraocular pressure. Taurine is one of the agents that have attracted attention of researchers recently. Taurine has been shown to be involved in multiple cellular functions, including a central role as a neurotransmitter, as a trophic factor in the central nervous system development, as an osmolyte, as a neuromodulator, and as a neuroprotectant. It also plays a role in the maintenance of the structural integrity of the membranes and in the regulation of calcium transport and homeostasis. Taurine is known to prevent N-methyl-D-aspartic acid-induced excitotoxic injury to retinal ganglion cells. A recently published study clearly demonstrated that taurine prevents retinal neuronal apoptosis both in vivo and in vitro. Protective effect of taurine may be attributed to direct inhibition of apoptosis, an activation of brain derived neurotrophic factor-related neuroprotective mechanisms and reduction of retinal oxidative and nitrosative stresses. Further studies are needed to fully explore the potential of taurine as a neuroprotective agent, so that it can be applied in clinical practice, particularly for the treatment of glaucoma. The objective of current review was to summarize recent evidence on neuroprotective properties of taurine in glaucoma.

Key words: apoptosis, excitotoxicity, glaucoma, oxidative and nitrosative stresses, retinal neuroprotection, taurine