脊髓损伤

Upregulation of circ0000381 attenuates microglial/macrophage pyroptosis after spinal cord injury

• Figure 3｜Microglia/macrophages play a key role in pathological progression after SCI.  

  

  To determine whether the upregulation of circ0000381 may affect microglial/macrophage pyroptosis after SCI, we performed double immunofluorescence staining for Iba-1, labeling both microglia and macrophages in the spinal cord with different pyroptosis markers including NLRP3, caspase-1, GSDMD, and IL1β. Compared with the sham group, fluorescence signal intensities in microglia/macrophages were significantly increased at 7 days post-SCI in the SCI group (Figure 3).

  
  

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发布日期： 2023-11-18  浏览： 51