中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (14): 1386-1388.doi: 10.4103/1673-5374.137592

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

超声检测壳聚糖神经导管桥接大鼠坐骨神经缺损

  

  • 收稿日期:2014-06-06 出版日期:2014-07-25 发布日期:2014-07-25
  • 基金资助:

    国家高技术研究发展计划(863计划) (2012AA020502)；国家自然科学基金项目(81171457，81371687)，基于江苏省优势学科建设项目

Ultrasound imaging of chitosan nerve conduits that bridge sciatic nerve defects in rats

Xiaoyang Chen 2, Yifei Yin 2, Tingting Zhang 2, Yahong Zhao3, Yumin Yang 3, Xiaomei Yu 2, Hongkui Wang 1, 3
   

  1. 1 School of Biology and Basic Medical Sciences, Soochow University, Suzhou, Jiangsu Province, China
    2 Department of Doppler Ultrasound, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
    3 Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China
  • Received:2014-06-06 Online:2014-07-25 Published:2014-07-25
  • Contact: Hongkui Wang, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, Jiangsu Province, China; Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China, wang-hongkui@ntu.edu.cn.
  • Supported by:

    The research is supported by the National High Technology Research and Development Program of China, No. 2012AA020502; the National Natural Science Foundation of China, No. 81171457 and 81371687; and the Priority of Academic Program Development of Jiangsu Higher Education Institutions.

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摘要：

自体神经修复周围神经损伤已被视为周围神经损伤修复的金标准(Wang et al., 2005; Yao et al., 2010; Deal et al., 2012; Kriebel et al., 2014; Liu et al., 2014; Tamaki et al., 2014; Yu et al., 2014; Zhu and Lou, 2014)，但随着组织工程和生物材料不断发展，使用多种材料和结构的组织工程化神经导管替代自体神经修复周围神经损伤已应用于临床(Wang et al., 2012; Sví?enská et al., 2013; Eppenberger et al., 2014; Gu et al., 2014; Koudehi et al., 2014; Moya-Díaz et al., 2014; Novajra et al., 2014; Okamoto et al., 2014; Shea et al., 2014; Singh et al., 2014; Tamaki et al., 2014; Yu et al., 2014)，因此，需要一种新的检测方法以观察其效果。超声是一种临床常用的无创检测方法，已在许多领域应用。但还未见超声观察植入体内的神经导管。Haug等(Haug et al., 2013)试图使用超声观察修复缺损神经的胶原神经导管，而这次我们首次使用超声观察了置入大鼠体内的壳聚糖神经导管随时间的变化特点。

Abstract:

The repair of peripheral nerve injuries with autologous nerve remains the gold standard (Wang et al., 2005; Yao et al., 2010; Deal et al., 2012; Kriebel et al., 2014; Liu et al., 2014; Tamaki et al., 2014; Yu et al., 2014; Zhu and Lou, 2014). With advances in tissue engineering and biomaterials, tissue-engineered nerve conduits with various biomaterials and structures, such as collagen and chitosan nerve conduits, have already been used in the clinic as alternatives to autologous nerve in the repair of peripheral nerve injury (Wang et al., 2012; Sví?enská et al., 2013; Eppenberger et al., 2014; Gu et al., 2014; Koudehi et al., 2014; Moya-Díaz et al., 2014; Novajra et al., 2014; Okamoto et al., 2014; Shea et al., 2014; Singh et al., 2014; Tamaki et al., 2014; Yu et al., 2014). Therefore, new simple and effective methods are needed to better evaluate the outcomes of repair using nerve conduits in vivo. Ultrasound is a common noninvasive clinical detection modality that has been used in many fields. However, ultrasound has only rarely been used to observe implanted nerve conduits in vivo. Haug et al. (2013) tried to displace the collagen nerve conduit for repairing the digital nerve under ultrasound. Here, we report the first use of ultrasound to noninvasively observe the changes in chitosan nerve conduits implanted in rats over time.