中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (30): 2325-2332.

• 原著:退行性病与再生 •    下一篇

蛇床子素调节中枢谷氨酸含量提高阿尔茨海默病模型大鼠海马突触可塑性和认知功能

  

  • 收稿日期:2012-03-12 修回日期:2012-07-10 出版日期:2012-10-25 发布日期:2012-10-25

Osthole improves synaptic plasticity in the hippocampus and cognitive function of Alzheimer’s disease rats via regulating glutamate

Xiaohua Dong 1, 2, Danshen Zhang 1, 2, Li Zhang2, Wei Li2, Xianyong Meng3   

  1. 1 Department of Pharmacology, College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China
    2 Department of Pharmacology, School of Medicine, Hebei North University, Zhangjiakou 075000, Hebei Province, China
    3 Department of Orthopedics, the First Attached Hospital, Hebei North University, Zhangjiakou 075000, Hebei Province, China
  • Received:2012-03-12 Revised:2012-07-10 Online:2012-10-25 Published:2012-10-25
  • Contact: Dan-shen Zhang, Ph.D., Profes-sor, Doctoral supervisor, Department of Pharmacolo-gy, College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China; Department of Pharmacology, School of Medicine, Hebei North Uni-versity, Zhangjiakou 075000, Hebei Province, China dszhang_cn@yahoo.com.cn
  • About author:Xiaohua Dong☆, Studying for doctorate, Associate professor, Department of Pharmacology, College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China; Department of Phar-macology, School of Medi-cine, Hebei North University, Zhangjiakou 075000, Hebei Province, China

PDF

907

Abstract:

Osthole, an effective monomer in Chinese medicinal herbs, can cross the blood-brain barrier and protect against brain injury, with few toxic effects. In this study, a rat model of Alzheimer’s disease was established after intracerebroventricular injection of β-amyloid peptide (25–35). Subsequently, the rats were intraperitoneally treated with osthole (12.5 or 25.0 mg/kg) for 14 successive days. Results showed that osthole treatment significantly improved cognitive impairment and protected hippocampal neurons of Alzheimer’s disease rats. Also, osthole treatment alleviated suppressed long-term potentiation in the hippocampus of Alzheimer’s disease rats. In these osthole-treated Alzheimer’s disease rats, the level of glutamate decreased, but there was no significant change in γ-amino-butyric acid. These experimental findings suggest that osthole can improve learning and memory impairment, and increase synaptic plasticity in Alzheimer’s disease rats. These effects of osthole may be because of its regulation of central glutamate and γ-amino-butyric acid levels.

Key words: osthole, Alzheimer’s disease, learning and memory, long-term potentiation, glutamate, γ-amino-butyric acid, β-amyloid peptide, brain, hippocampus, neural regeneration