中国神经再生研究(英文版)

中国神经再生研究(英文版)

• 观点:神经损伤修复保护与再生 •    下一篇

Angioplasty and stenting for severe vertebral artery orifice stenosis: effects on cerebellar function remodeling verified by blood oxygen level-dependent functional MRI

  

  • 出版日期:2014-01-01 发布日期:2014-01-01

Angioplasty and stenting for severe vertebral artery orifice stenosis: effects on cerebellar function remodeling verified by blood oxygen level-dependent functional MRI

Bo Liu 1, 2, 3, Zhiwei Li 1, Peng Xie 1, 2, 3, 4   

  1. 1 Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China
    2 Institute of Neuroscience, Chongqing Medical University, Chongqing, China
    3 Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, China
    4 Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • Online:2014-01-01 Published:2014-01-01
  • Supported by:

    This study was supported by the Natural Science Foundation of Yongchuan District of Chongqing Municipality, No. Ycstc,2013nc8031; the Foundation of Chongqing Municipal Health Bureau, No. 2010-2-250; the Foundation of Chongqing Health and Family Planning Commission, No. 20143001; the Soft Science Foundation of Yongchuan District of Chongqing Municipality, No. Ycstc, 2011BE5004.

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Abstract:

Vertebral artery orifice stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebral blood flow and perfusion in the posterior circulation after interventional therapy. This study examined the effects of functional recovery of local brain tissue on cerebellar function remodeling using blood oxygen level-dependent functional magnetic resonance imaging before and after interventional therapy. A total of 40 Chinese patients with severe unilateral vertebral artery orifice stenosis were enrolled in this study. Patients were equally and randomly assigned to intervention and control groups. The control group received drug treatment only. The intervention group received vertebral artery orifice angioplasty and stenting + identical drug treatment to the control group. At 13 days after treatment, the Dizziness Handicap Inventory score was compared between the intervention and control groups. Cerebellar function remodeling was observed between the two groups using blood oxygen level-dependent functional magnetic resonance imaging. The improvement in dizziness handicap and cerebellar function was more obvious in the intervention group than in the control group. Interventional therapy  for severe vertebral artery orifice stenosis may effectively promote cerebellar function remodeling and exert neuroprotective effects.

Key words: nerve regeneration, posterior circulation ischemia, vertebrobasilar insufficiency, dizziness, Dizziness Handicap Inventory, vertebral artery stenosis, angioplasty and stenting, endovasculartreatment, functional magnetic resonance imaging, cerebellar function remodeling, cerebral vessels, atheromatous plaque, neural regeneration