中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (2): 198-200.doi: 10.4103/1673-5374.152367

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓损伤后自噬在轴突变性中的作用:轴索回缩球内的自噬体生物合成证据

  

  • 收稿日期:2015-01-14 出版日期:2015-02-17 发布日期:2015-02-17

Autophagy in degenerating axons following spinal cord injury: evidence for autophagosome biogenesis in retraction bulbs

Vinicius T. Ribas, Paul Lingor   

  1. Department of Neurology, University Medicine Göttingen, 37075 Göttingen, Germany (Ribas VT, Lingor P)
    Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany (Lingor P)
  • Received:2015-01-14 Online:2015-02-17 Published:2015-02-17
  • Contact: Paul Lingor, M.D., plingor@gwdg.de.
  • Supported by:

    VTR is a fellow of the National Council for Scientific and Technological Development (CNPq), Brazil. PL was funded by the International Foundation for Research in Paraplegia (IRP-P 112) and the Deutsche Forschungsgemeinschaft (DFG-LI 1308/3-1) and the Else Kröner-Fresenius-Stiftung.

摘要:

大自噬是一种体内平衡机制,负责降解零散细胞质、长寿蛋白和整个细胞器,其特征是称为自噬体的双膜泡形成。先前已经有证据表明,健康的新生轴突自噬体形式和吞噬产物在轴突末端优先形成。几项研究显示出轴突变性可诱导自噬,但缺乏脊髓损伤后轴突自噬相关蛋白的精确表征。