中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (7): 1018-1022.doi: :10.4103/1673-5374.160094

• 综述:退行性病与再生 • 上一篇    下一篇

脑深刺激治疗帕金森病:当前的问题?

  

  • 收稿日期:2015-05-08 出版日期:2015-07-24 发布日期:2015-07-24

The treatment of Parkinson’s disease with deep brain stimulation: current issues

Alexia-Sabine Moldovan, Stefan Jun Groiss, Saskia Elben, Martin Südmeyer, Alfons Schnitzler, Lars Wojtecki   

  1. Center for Movement Disorders and Neuromodulation, Department of Neurology, University Hospital Düsseldorf, Germany & Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
  • Received:2015-05-08 Online:2015-07-24 Published:2015-07-24
  • Contact: Lars Wojtecki, M.D., wojtecki@uni-duesseldorf.de.
  • Supported by:

    This study was supported by ERA-NET Neuron /German Federal Ministry of Education and Research (BMBF): TYMON 01EW141 to LW.

摘要:

脑深刺激在过去的25年中已成为公认的治疗帕金森病的经典方法。这种方法除了能够改善症状和长期运动并发症以外,其对患者行动力,日常生活活动等都有积极影响,另外脑深刺激对情绪健康和生命健康的改善效果也都得到了认可。除了这些疗效外,许多临床试验也分析了非运动症状和脑深刺激的副作用影响。用以优化治疗效果、减少副作用和方便利用的几个技术问题和刺激范式已经并仍在开发中。

Abstract:

Deep brain stimulation has become a well-established symptomatic treatment for Parkinson’s disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients’ mobility, activities of daily living, emotional well-being and health-related quality of life have been recognized. Apart from that, numerous clinical trials analyzed effects on non-motor symptoms and side effects of deep brain stimulation. Several technical issues and stimulation paradigms have been and are still being developed to optimize the therapeutic effects, minimize the side effects and facilitate handling. This review summarizes current therapeutic issues, i.e., patient and target selection, surgical procedure and programming paradigms. In addition it focuses on neuropsychological effects and side effects of deep brain stimulation.

Key words: Parkinson’s disease, deep brain stimulation, subthalamic nucleus