中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (27): 2085-2091.

• 原著:脑损伤修复保护与再生 •    下一篇

免疫调节药物Setarud对脑缺血的神经保护效应

  

  • 收稿日期:2012-03-18 修回日期:2012-06-13 出版日期:2012-09-25 发布日期:2012-09-25

Neuroprotective effects of the immunomodulatory drug Setarud on cerebral ischemia in male rats

Farzaneh Vafaee1, Nasser Zangiabadi2, Fatemeh Mehdi Pour3, Farzaneh Dehghanian3, Majid Asadi-Shekaari2, Hossein Karimi Afshar4   

  1. 1 Neuroscience Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    2 Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
    3 Member of Research Committee, Kerman University of Medical Sciences, Kerman, Iran
    4 Member of Research Committee, Kerman University of Medical Sciences, Kerman, Iran
  • Received:2012-03-18 Revised:2012-06-13 Online:2012-09-25 Published:2012-09-25
  • Contact: Majid Asadi-Shekaari, Associate professor of histology, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran majidasadi@kmu.ac.ir
  • About author:Farzaneh Vafaee★, MS.c., Lecturer, Associate professor of histology, Neuroscience Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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Abstract:

Anti-inflammatory and anti-oxidant agents can alleviate ischemic cerebral injury. The immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica and Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory and anti-oxidant properties. Therefore, we hypothesized that Setarud will have a neuroprotective effect against ischemic cerebral injury. To validate this hypothesis, rats were intraperitoneally administered with 0.66 mL/kg Setarud for 30 minutes after middle cerebral artery occlusion. Triphenyltetrazolium chloride staining showed that Setarud could reduce cerebral infarct volume of rats subjected to cerebral ischemia. Transmission electron microscopy and hematoxylin-eosin staining results showed that Setarud could alleviate the degenerative changes in cortical neurons of rats with cerebral ischemia. The inclined plate test and prehensile test showed that Setarud could significantly improve the motor function of rats with cerebral ischemia. These findings suggest that Setarud shows neuroprotective effects against ischemic brain injury.

Key words: immunomodulatory drug, stroke, prehensile test, antioxidant, inclined plate test, cerebral infarct, cortex, neuroprotection, brain injury, neural regeneration