中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (9): 1386-1387.doi: 10.4103/1673-5374.165244

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

发育过程中大脑接受麻醉可诱导少突胶质细胞的变化?

  

  • 收稿日期:2015-06-29 出版日期:2015-09-28 发布日期:2015-09-28

The changes of oligodendrocytes induced by anesthesia during brain development

Danye Jiang, Sanghee Lim, Minhye Kwak, Yun Kyoung Ryu, C. David Mintz   

  1. Department of Anesthesiology and Critical Care Medicine, Johns
    Hopkins Medical Institutes, Baltimore, MD, USA
  • Received:2015-06-29 Online:2015-09-28 Published:2015-09-28
  • Contact: C. David Mintz, M.D., Ph.D., cmintz2@jhmi.edu.
  • Supported by:

    This study was supported by NIH 1K08GM104329 to CDM.

摘要:

随着现代医药技术的发展,全身麻醉不太可能对人体造成伤害。但新出现的临床和实验室研究已经表明,童年时长期暴露于麻醉条件可能会对认知功能造成不利的影响。神经胶质细胞是麻醉中毒的可能目标。童年早期接触麻醉剂会造成星形胶质细胞骨架中断,同时其对神经元生长的支持能力也会暂时受损。发育期大脑中麻醉诱导的少突胶质细胞细胞凋亡是实质存在的,在儿科麻醉中关注神经毒性是一个有前途的研究领域。

Abstract:

With the advent of modern techniques, drugs, and monitoring, general anesthesia has come to be considered an unlikely cause of harm, particularly for healthy patients. While this is largely true, newly emerging clinical and laboratory studies have suggested that exposure to anesthetic agents during early childhood may have long-lasting adverse effects on cognitive function. The evidence strongly suggests that glia are a possible target of anesthetic toxicity. Astrocytes clearly undergo cytoskeletal disruption as a result of early anesthetic exposure and their capacity to support neuronal growth is transiently impaired. These results have been obtained using dissociated culture models, and must still be translated to the context of the intact brain. Anesthetics induce apoptotic cell death in a substantial population of oligodendrocytes in the developing brain, but the significance of this finding will be greatly enhanced if it is shown to be persistent. The currently available literature on the effects of anesthetics on glia in the developing brain is fairly sparse compared to studies of developmental anesthetic toxicity in neurons, and we conclude that this is a promising area for further study in the field of pediatric anesthetic neurotoxicity.