中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (9): 1390-1392.doi: 10.4103/1673-5374.165502

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

表没食子儿茶素没食子酸酯下调损伤脊髓的RhoA表达

  

  • 收稿日期:2015-08-01 出版日期:2015-09-28 发布日期:2015-09-28

Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury

Pere Boadas-Vaello, Enrique Verdú   

  1. Research Group of Clinical Anatomy, Embryology, and Neuroscience (NEOMA), Universitat de Girona, Faculty of Medicine, Department of Medical Sciences, Girona, Spain
  • Received:2015-08-01 Online:2015-09-28 Published:2015-09-28
  • Contact: Pere Boadas-Vaello, Ph.D., pere.boadas@udg.edu.
  • Supported by:

    The present work was funded by Accions Singulars de R+D (Sing 12/17) del Vicerectorat de Recerca de la Universitat de Girona, Girona, Spain.

摘要:

表没食子儿茶素-3-没食子酸酯可以调节脊髓损伤后相关细胞信号传导途径,继而掌控神经元的存活,轴突和髓鞘再生,并通过调节星形胶质细胞和小胶质细胞的反应促进运动恢复和减轻神经损伤后神经性疼痛。因此,这些发现为开发高效力儿茶素-衍生物用于增强轴突再生,保护脑和/或脊髓实质,以及外周和中枢神经系统损伤后减少神经胶质增生提供了新依据。Boadas-Vaello 博士指出,与天然儿茶素化合物相比,新的儿茶素衍生物更能减轻坐骨神经的慢性缩窄性损伤后热痛过敏反应。此外,作者的研究还表明,儿茶素治疗减轻脊髓损伤后的热痛觉过敏,以及在神经性疼痛实验模型中,儿茶素的作用机制与降低促炎性细胞因子的表达和调制的转录因子和RhoA蛋白在脊髓中的表达相关。

Abstract:

The epigallocatechin-3-gallate (EGCG) treatment may be a potential drug to promote neuroprotection and functional recovery after nervous system injury. However, additional experimental research will be necessary to further explore the biological mechanisms of this polyphenol in order to become a suitable and safe therapeutic treatment.