中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1725-1726.doi: 10.4103/1673-5374.170287

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

血管内皮生长因子:研究神经再生的重要靶点 

  

  • 收稿日期:2015-10-08 出版日期:2015-12-07 发布日期:2015-12-07

VEGF in the nervous system: an important target for research in neurodevelopmental and regenerative medicine

Matthias Dumpich, Carsten Theiss*   

  1. Faculty of Medicine, Institute of Anatomy, Department of Cytology Ruhr-University Bochum, Bochum, Germany
  • Received:2015-10-08 Online:2015-12-07 Published:2015-12-07
  • Contact: Carsten Theiss, Ph.D., carsten.theiss@rub.de.
  • Supported by:

    Matthias Dumpich would like to thank the Heinrich and Alma Vogelsang Foundation for financial support in the form of a graduation scholarship. We would also like to acknowledge D. Terheyden-Keighley for the critical reading of this paper.

摘要:

神经元发育以及神经元损伤中血管内皮生长因子及其受体的表达和调控。在不利轴突生长的环境下,血管内皮生长因子能增强神经保护作用;血管内皮生长因子主要通过介导肌动蛋白骨架的重组,发挥轴突导向作用,但具体信号传导的下游信号尚未明确。作者认为,未来可以通过血管内皮生长因子刺激轴突生长辅助支持脊髓损伤或轴索损害后复原或再生过程。此外,通过血管内皮生长因子对缺血损伤大脑的神经保护机制,可为神经系统疾病的治疗提供新的思路。

Abstract:

VEGF is highly involved in axonal growth, neurodevelopment and in the pathogenesis of different neurological disorders. It enhances neuroprotection under unfavorable conditions and supports the growth of cerebral tumor tissue. VEGF’s effects in axon guidance are primarily mediated via reorganization of the actin cytoskeleton, but the exact downstream signaling of VEGF-signaling is not clear yet. All of those aspects lead us to suspect that VEGF will play a big role in upcoming neurological investigations and clinical treatments. It is conceivable that stimulation of axonal growth via VEGF will be used to support rehabilitation or regenerative processes after spinal-cord injuries or axonal damage. Furthermore, the therapies of cerebral tumors by inhibition of VEGF, or the support of neuroprotective mechanisms after ischemic insults by up-regulation of VEGF, are therapeutical options that might be of interest to future investigations.