中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1773-1776.doi: 10.4103/1673-5374.169639

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

  多因素影响脊髓发育

  

  • 收稿日期:2015-09-29 出版日期:2015-12-07 发布日期:2015-12-07

Factors influencing the spinal motoneurons in development

Stefan Wiese*   

  1. Faculty for Biology and Biotechnology, Group for Molecular Cell Biology, Universitaetsstr. 150, Ruhr University Bochum, D-44801 Bochum,
    Germany
  • Received:2015-09-29 Online:2015-12-07 Published:2015-12-07
  • Contact: Stefan Wiese, Ph.D., stefan.wiese@rub.de.

摘要:

脊髓发育需要的一系列转录因子会相互作用并通过作用于外部的不同细胞激活多样化基因和信号。而信号会作用在脊髓段以及在头脚轴和背腹轴。另外,运动神经元的轴突必须要穿越中枢神经系统障碍连接到周围神经。精密解剖研究已经随后表示转录因子的不同子集具有脊髓发育细胞中表达的分子表征。在这里,对这种最重要的出现细胞精密研究中,运动神经元已给出了对这些蛋白的表达模式的良好了解。尽管如此,运动神经元在所有细胞的相互作用活动中远不是唯一重要的细胞,它们除了是脊髓中正确功能必要的细胞外,也是保持运动神经元完整性的基础之一。

Abstract:

 The development of the spinal cord needs a concerted interaction of transcription factors ac¬tivating diverse genes and signals from outside acting on the specification of the different cells. Signals have to act on the segments of the embryo as well as on the cranial-caudal axis and the dorso-ventral axis. Additionally the axons of the motoneurons have to cross the central nervous system barrier to connect to the periphery. Intensive anatomical studies have been followed by molecular characterization of the different subsets of transcription factors that are expressed by cells of the developing spinal cord. Here, intensive studies for the most important appearing cells, the motoneurons, have resulted in a good knowledge on the expression patterns of these pro¬teins. Nonetheless motoneurons are by far not the only important cells and the concert activity of all cells besides them is necessary for the correct function and integrity of motoneurons within the spinal cord. This article will briefly summarize the different aspects on spinal cord develop¬ment and focuses on the differentiation as well as the functionalization of motoneurons.