中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (1): 47-52.doi: 10.4103/1673-5374.198973

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

富含血小板血浆:辅助生物治疗促进周围神经修复

  

  • 收稿日期:2016-12-16 出版日期:2017-01-15 发布日期:2017-01-15

Platelet-rich plasma, an adjuvant biological therapy to assist peripheral nerve repair

Mikel Sánchez1, 2, Ane Garate2, Diego Delgado2, *, Sabino Padilla3, *   

  1. 1. Arthroscopic Surgery Unit, Hospital Vithas San José, Vitoria-Gasteiz, Spain; 
    2. Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA; 
    3. BTI Biotechnology Institute, Vitoria-Gasteiz, Spain
  • Received:2016-12-16 Online:2017-01-15 Published:2017-01-15
  • Contact: Mikel Sánchez, Ph.D. or Diego Delgado, Ph.D., mikel.sanchez@ucatrauma.com or diego.delgado@ucatrauma.com.

摘要:

诸如直接无张力显微外科修复或神经自体移植的移植治疗手段如今已用于治疗创伤性周围神经损伤,这些治疗方法集中于增强受损轴突的内在再生潜能。然而,这些治疗并不能重建周围神经修复的合适细胞和分子微环境,并且在一些情况下,神经损伤的功能恢复是不完全的。因此,当前基于组织工程方法通过分子干预和支架的新生物医学工程策略提供了有前途的结果。在这个意义上,临床前和临床条件下的研究证据表明富血小板血浆产品和从该技术获得的血纤维蛋白支架具有作为神经保护,神经源性和神经炎症治疗调节剂系统的重要治疗潜力,如增强感觉和运动功能的神经肌肉单位恢复。

ORCID:0000-0001-9992-6927(Mikel Sánchez)

Abstract:

Therapies such as direct tension-free microsurgical repair or transplantation of a nerve autograft, are nowadays used to treat traumatic peripheral nerve injuries (PNI), focused on the enhancement of the intrinsic regenerative potential of injured axons. However, these therapies fail to recreate the suitable cellular and molecular microenvironment of peripheral nerve repair and in some cases, the functional recovery of nerve injuries is incomplete. Thus, new biomedical engineering strategies based on tissue engineering approaches through molecular intervention and scaffolding offer promising outcomes on the field. In this sense, evidence is accumulating in both, preclinical and clinical settings, indicating that platelet rich plasma (PRP) products, and fibrin scaffold obtained from this technology, hold an important therapeutic potential as a neuroprotective, neurogenic and neuroinflammatory therapeutic modulator system, as well as enhancing the sensory and motor functional nerve muscle unit recovery.

Key words: peripheral nerve injuries (PNI), Schwann cells (SC), axons, platelet rich plasma (PRP), biomolecules, fibrin, scaffold, intraneural, perineural, microenvironment