中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (2): 197-200.doi: 10.4103/1673-5374.200796

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

纳米疗法在脑肿瘤靶向药物递送方法的巨大潜力

  

  • 收稿日期:2017-02-06 出版日期:2017-02-15 发布日期:2017-02-15

The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches

Vivek Agrahari   

  1. School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA
  • Received:2017-02-06 Online:2017-02-15 Published:2017-02-15
  • Contact: Vivek Agrahari, Ph.D.,vahw2@mail.umkc.edu.

摘要:

 

2016年根据国家脑肿瘤学会报道约688,096名美国人患有脑肿瘤(http://braintumor.org/brain-tumor-information/brain-tumor-facts/)。 据估计,预测2016年将有约78,000人被诊断患有脑肿瘤,16,616人死于该疾病。脑肿瘤对治疗学极具挑战性,治疗受限于缺乏有效的化疗药物递送方法,这需穿过中枢神经系统屏障。 目前可用的治疗手段包括手术切除,其次是免疫治疗,放射治疗和化疗。 然而,当前的治疗方法获益对于患者来说几乎没有意义。 基于上述事实,在该篇文章中,我们简要讨论了使用纳米载体系统将中枢神经系统药物递送至脑肿瘤区域的方法。

 

ORCID:0000-0002-3837-1777(Vivek Agrahari)

Abstract:

Delivering therapeutics to the central nervous system (CNS) and brain-tumor has been a major challenge. The current standard treatment approaches for the brain-tumor comprise of surgical resection followed by immunotherapy, radiotherapy, and chemotherapy. However, the current treatments are limited in providing significant benefits to the patients and despite recent technological advancements; brain-tumor is still challenging to treat. Brain-tumor therapy is limited by the lack of effective and targeted strategies to deliver chemotherapeutic agents across the blood-brain barrier (BBB). The BBB is the main obstacle that must be overcome to allow compounds to reach their targets in the brain. Recent advances have boosted the nanotherapeutic approaches in providing an attractive strategy in improving the drug delivery across the BBB and into the CNS. Compared to conventional formulations, nanoformulations offer significant advantages in CNS drug delivery approaches. Considering the above facts, in this review, the physiological/anatomical features of the brain-tumor and the BBB are briefly discussed. The drug transport mechanisms at the BBB are outlined. The approaches to deliver chemotherapeutic drugs across the CNS into the brain-tumor using nanocarriers are summarized. In addition, the challenges that need to be addressed in nanotherapeutic approaches for their enhanced clinical application in brain-tumor therapy are discussed.

Key words: brain-tumor, glioma, CNS, blood-brain barrier, drug transport, nanoformulation, nanocarrier, cell-mediated drug delivery