中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (24): 1881-1888.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

抑郁症患者神经环路的影像学改变：弥散张量成像和磁共振波谱成像表现

  

  • 收稿日期:2012-03-15 修回日期:2012-06-19 出版日期:2012-08-25 发布日期:2012-08-25

Imaging changes in neural circuits in patients with depression using 1H-magnetic resonance spectroscopy and diffusion tensor imaging

Shaoqiong Chen1, Lisha Lai1, Zhuang Kang1, Xiao Luo1, Jiansheng Zhang1, Jianfang Li2   

  1. 1 Department of Radiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
    2 Department of Nuclear Medicine, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
  • Received:2012-03-15 Revised:2012-06-19 Online:2012-08-25 Published:2012-08-25
  • Contact: Shaoqiong Chen, Depart-ment of Radiology, the Third Affiliated Hospital, Sun Yat-sen University, Guang-zhou 510630, Guangdong Province, China csq_q@yahoo.com
  • About author:Shaoqiong Chen☆, M.D., Ph.D., Associate chief physician, Department of Radiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China

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Abstract:

1H-magnetic resonance spectroscopy imaging and diffusion tensor imaging were performed in 19 patients with mild depression and in 13 controls. The mean age of the patients was 31 years. The mean Hamilton depression score of the patients was 22.5 ± 13.2. N-acetylaspartate, choline and creatine concentrations and the average diffusion coefficient and fractional anisotropy values were measured in the bilateral hippocampus, striatum, thalamus and prefrontal deep white matter. Compared with the control group, the mild depressed patients had: (1) a higher choline/creatine ratio and a negative correlation between the choline/creatine ratio and the average diffusion coefficient in the hippocampus; (2) a lower choline/creatine ratio and a higher fractional anisotropy in the striatum; (3) a lower fractional anisotropy and a positive correlation between the fractional anisotropy and the choline/creatine ratio in the prefrontal deep white matter; and (4) a higher average diffusion coefficient and a positive correlation between the choline/creatine ratio and the N-acetylaspartate/creatine ratio in the thalamus, as well as positive correlation between the cho-line/creatine ratio and Hamilton depression scores. These data suggest evidence of abnormal connectivity in neurofibrotic microstructures and abnormal metabolic alterations in the lim-bic-cortical-striatal-pallidal-thalamic neural circuit in patients with mild depression.

Key words: depression, diffusion tensor imaging, hippocampus, magnetic resonance spectroscopy, nerve fiber, neural circuit, neurotransmitter, neural regeneration