1 The molecular and cellular events underlying the robust inflammatory response in acute spinal cord injury are key targets for potential pharmacological therapies.
2 Appropriate modulation of post-traumatic inflammation, to augment its beneficial aspects and attenuate its detrimental aspects, may promote functional recovery.
3 Anti-inflammatory mechanisms of systemic hypothermia, and minocycline and erythropoietin therapies, suggest the promise of clinical interventions for spinal cord injury, without the risks associated with high dose steroid therapy.
4 Preclinical therapeutic agents studied in experimental models should continue to be pursued to establish more effective treatments for inflammation after acute spinal cord injury.
1 急性脊髓损伤后分子与细胞的活动是炎症反应中是潜在药物治疗的主要目标。
2 创伤后炎症的适当调制来增强有利方面,减弱不利方面,可促进功能恢复。
3 全身体温过低的抗炎机制,米诺环素和促红细胞生成素治疗为脊髓损伤临床干预带来希望,而且没有高剂量类固醇治疗的风险。
4 应继续开展试验模型的临床前治疗药物研究,建立急性脊髓损伤后的炎症更有效的治疗。