中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (3): 513-518.doi: 10.4103/1673-5374.350192

• 综述:退行性病与再生 • 上一篇    下一篇

炎症和视网膜退行性疾病

  

  • 出版日期:2023-03-15 发布日期:2022-08-25

Inflammation and retinal degenerative diseases

Geetika Kaur1, 2, Nikhlesh K. Singh1, 2, *   

  1. 1Integrative Biosciences Center, Wayne State University, Detroit, MI, USA; 2Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USA
  • Online:2023-03-15 Published:2022-08-25
  • Contact: Nikhlesh K. Singh, DVM, PhD, nsingh2@wayne.edu.
  • Supported by:
    The work was supported by a National Institutes of Health grant, EY029709 (to NKS), and a Research to Prevent Blindness unrestricted grant to Kresge Eye Institute, and by P30EY04068 (LDH) at Wayne State University (to NKS). 

摘要: https://orcid.org/0000-0002-3665-6023 (Nikhlesh K. Singh) 

Abstract: Vision is an ability that depends on the precise structure and functioning of the retina. Any kind of stress or injury can disrupt the retinal architecture and leads to vision impairment, vision loss, and blindness. Immune system and immune response function maintain homeostasis in the microenvironment. Several genetic, metabolic, and environmental factors may alter retinal homeostasis, and these events may initiate various inflammatory cascades. The prolonged inflammatory state may contribute to the initiation and development of retinal disorders such as glaucoma, age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, which pose a threat to vision. In the current review, we attempted to provide sufficient evidence on the role of inflammation in these retinal disorders. Moreover, this review paves the way to focus on therapeutic targets of the disease, which are found to be promising.

Key words: age-related macular degeneration, diabetic retinopathy, glaucoma, retina, retinal degeneration, retinitis pigmentosa