中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (4): 734-745.doi: 10.4103/1673-5374.353481

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

微小RNA:神经元生长和发育过程中的保护性调节器

  

  • 出版日期:2023-04-15 发布日期:2022-10-27

MicroRNAs: protective regulators for neuron growth and development

Zhi-Xuan Ma1, Zhen Liu2, Hui-Hui Xiong2, Zong-Pu Zhou1, Li-Si Ouyang2, Fu-Kang Xie2, Ya-Mei Tang3, Zhong-Dao Wu4, *, Ying Feng1, *   

  1. 1School of Medicine, South China University of Technology, Guangzhou, Guangdong Province, China;  2Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China;  3Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China;  4Key Laboratory of Tropical Disease Control, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China
  • Online:2023-04-15 Published:2022-10-27
  • Contact: Ying Feng, MD, PhD, fengy8@scut.edu.cn; Zhong-Dao Wu, MD, PhD, wuzhd@mail.sysu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81801208 (to LSO); Science and Technology Program of Guangzhou, No. 202102080053 (to YF); Science and Technology Planning Project of Guangzhou, No. 202102020027 (to ZL); Science and Technology Program of Guangzhou, No. 202007030001 (to YMT).

摘要:


众所周知,微小RNA(miRNAs)在神经元的生长和发育中起着重要的调节作用。不同的miRNA针对不同的基因,以不同的方式保护神经元,如避免细胞凋亡,防止条件性介质介导的变性,防止神经元丢失,削弱某些神经毒性机制,减轻炎症对神经元的损伤。微小RNA在大脑中的高表达在很大程度上促进了miRNA作为治疗的保护性标靶的研究发展,涉及神经保护和神经元恢复。微小RNA在神经元的生长和发育中不可或缺,且对大脑的发育和神经系统疾病的发展也是有益的。此综述介绍了miRNA在不同疾病或损伤模型中对神经元的保护作用,并为后续研究提供参考价值和治疗思路。

https://orcid.org/0000-0001-6961-4084 (Ying Feng); https://orcid.org/0000-0001-5879-9757 (Zhong-Dao Wu)

Abstract: MicroRNAs (miRNAs) play an important regulatory role in neuronal growth and development. Different miRNAs target different genes to protect neurons in different ways, such as by avoiding apoptosis, preventing degeneration mediated by conditional mediators, preventing neuronal loss, weakening certain neurotoxic mechanisms, avoiding damage to neurons, and reducing inflammatory damage to them. The high expression of miRNAs in the brain has significantly facilitated their development as protective targets for therapy, including neuroprotection and neuronal recovery. miRNA is indispensable to the growth and development of neurons, and in turn, is beneficial for the development of the brain and checking the progression of various diseases of the nervous system. It can thus be used as an important therapeutic target for models of various diseases. This review provides an introduction to the protective effects of miRNA on neurons in case of different diseases or damage models, and then provides reference values and reflections on the relevant treatments for the benefit of future research in the area. 

Key words: brain damage, miRNA, neurodegenerative disorders, neuronal apoptosis, neuronal protection