中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (6): 1267-1268.doi: 10.4103/1673-5374.360169

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

功能失调的 cGMP 信号传导导致小鼠与年龄相关的视网膜血管改变和星形胶质细胞重塑

  

  1. 眼科与视觉科学系,范德比尔特眼科研究所,范德比尔特大学医学中心,美国
  • 出版日期:2023-06-15 发布日期:2022-12-22

cGMP signaling: a potential therapeutic target for neurodegeneration in glaucoma?

Joseph M. Holden, Lauren K. Wareham*   

  1. Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN, USA
  • Online:2023-06-15 Published:2022-12-22
  • Contact: Lauren K. Wareham, PhD,lauren.wareham@vumc.org.

摘要: https://orcid.org/0000-0003-4512-6355 (Lauren K. Wareham) 

Abstract: Neurodegeneration of the central nervous system (CNS) underscores many of humanity’s most debilitating diseases, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Recently, the nitric oxide-guanylate cyclase-cyclic guanosine monophosphate (NO-GC-cGMP) signaling pathway has gained traction as a neuroprotective pathway in the CNS. As an extension of the CNS, the retina is also susceptible to neurodegeneration with age. The most prevalent optic neuropathy is glaucoma, the world’s leading cause of irreversible blindness, predicted to affect more than 112 million people worldwide by 2040 (Calkins, 2021). In glaucoma, vision loss occurs due to the progressive degeneration of retinal ganglion cells (RGCs), the output neurons of the retina, along with their axons which form the optic nerve (Wareham et al., 2022). Degeneration of RGCs leads to a characteristic pattern of scotopic visual field deficiencies that spread from one retinotopic sector to the next (Elze et al., 2015). Visual deficits are linked to increasing age and the sensitivity of RGCs to intraocular pressure  (Calkins, 2021).