中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (7): 1411-1416.doi: 10.4103/1673-5374.360243

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

丝氨酸和精氨酸丰富的剪接因子1:神经保护和其他疾病的潜在靶标

  


  • 出版日期:2023-07-15 发布日期:2023-01-11

Serine and arginine rich splicing factor 1: a potential target for neuroprotection and other diseases

Ana M. Sandoval-Castellanos1, 2, #, Anushka Bhargava1, #, Min Zhao2, §, Jun Xu3, §, Ke Ning1, 3, *, §   

  1. 1Sheffield Institute of Translational Neuroscience, SITraN, The University of Sheffield, Sheffield, UK; 2Department of Ophthalmology & Vision Science, and Department of Dermatology, Institute for Regenerative Cures, University of California at Davis, School of Medicine, Sacramento, CA, USA; 3East Hospital, Tongji University School of Medicine, Shanghai, China
  • Online:2023-07-15 Published:2023-01-11
  • Contact: Ke Ning, PhD, k.ning@sheffield.ac.uk.

摘要: https://orcid.org/0000-0002-0771-1134 (Ke Ning) 

Abstract: Alternative splicing is the process of producing variably spliced mRNAs by choosing distinct combinations of splice sites within a messenger RNA precursor. This splicing enables mRNA from a single gene to synthesize different proteins, which have different cellular properties and functions and yet arise from the same single gene. A family of splicing factors, Serine-arginine rich proteins, are needed to initiate the assembly and activation of the spliceosome. Serine and arginine rich splicing factor 1, part of the arginine/serine-rich splicing factor protein family, can either activate or inhibit the splicing of mRNAs, depending on the phosphorylation status of the protein and its interaction partners. Considering that serine and arginine rich splicing factor 1 is either an activator or an inhibitor, this protein has been studied widely to identify its various roles in different diseases. Research has found that serine and arginine rich splicing factor 1 is a key target for neuroprotection, showing its promising potential use in therapeutics for neurodegenerative disorders. Furthermore, serine and arginine rich splicing factor 1 might be used to regulate cancer development and autoimmune diseases. In this review, we highlight how serine and arginine rich splicing factor 1 has been studied concerning neuroprotection. In addition, we draw attention to how serine and arginine rich splicing factor 1 is being studied in cancer and immunological disorders, as well as how serine and arginine rich splicing factor 1 acts outside the central or peripheral nervous system.

Key words: alternative splicing, autoimmune disorders, cancer, hypertension, mRNA, neuroprotection, splicing factors, SRSF1