中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (8): 1705-1706.doi: 10.4103/1673-5374.363826

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

突触后神经元中的 Ca 2+ 信号传导:Neuroplastin-65 调节质膜 Ca 2+ ATP 酶和离子型谷氨酸受体之间的相互作用

  

  • 出版日期:2023-08-15 发布日期:2023-02-16

Neuroplastin in Ca2+ signal regulation and plasticity of glutamatergic synapses

Ayse Malci#, Xiao Lin#, Yun Stone Shi, Rodrigo Herrera-Molina*   

  1. Center for Neuroscience Research, Children’s National Medical Center, Washington, DC, USA (Malci A) 
    Guangdong Institute of Intelligence Science and Technology, Zhuhai, Guangdong Province, China (Lin X, Shi YS)
    Combinatorial Combinatorial NeuroImaging, Leibniz Institute for Neurobiology, Magdeburg, Germany (Herrera-Molina R)
    Centro Integrativo de Biología y Química Aplicada, Universidad Bernardo O’Higgins, Santiago, Chile (Herrera-Molina R) 
  • Online:2023-08-15 Published:2023-02-16
  • Contact: Rodrigo Herrera-Molina, PhD, rherrera@lin-magdeburg.de.

摘要: https://orcid.org/0000-0001-9597-5131 (Rodrigo Herrera-Molina)

Abstract: The main function of neurons is information transmission in the form of action potentials. To fulfill this duty, neurons are connected functionally with each other via synapses, the microscopic structures where specialized molecular machinery is strategically placed to release and receive neurotransmitters and to generate and extinguish calcium (Ca2+) signals. These synaptic molecular components are highly dynamic and they influence each other to confer structural and functional adaptability (plasticity) to neuronal communication (Biederer et al., 2017). Recently, neuroplastin (Np), a cell recognition molecule, has emerged to play diverse neuronal functions including synapse formation, spine structure, Ca2+ signal regulation, excitatory/inhibitory balance, and synaptic plasticity. Evidence from different labs has converged to form a coherent picture; however, the uncovered mechanisms may represent only the tip of Np’s iceberg. Many questions remain to be answered. For example, why do neurons need two Np isoforms? How do Np isoforms contribute to Ca2+ signal regulation and synaptic plasticity?