中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (8): 1727-1727.doi: 10.4103/1673-5374.361669

• 观点:退行性病与再生 • 上一篇    下一篇

不给糖就捣乱? 癌症是否通过模仿轴突来促进转移到神经来愚弄许旺细胞?

  

  • 出版日期:2023-08-15 发布日期:2023-02-23

Trick or treat? Does cancer fool Schwann cells by mimicking axons to promote metastasis into nerves?

Peter Arthur-Farraj*   

  1. John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
  • Online:2023-08-15 Published:2023-02-23
  • Contact: Peter Arthur-Farraj, MBBS, PhD, pja47@cam.ac.uk.
  • Supported by:
    PAF was funded by a Clinical Research Career Development Fellowship from the Wellcome Trust (UK), 206634/Z/17/Z. For the purpose of Open Access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. 

摘要: https://orcid.org/0000-0002-1239-9392 (Peter Arthur-Farraj)

Abstract: The Schwann cell reaction to nerve injury, termed the repair program, is crucial to successful nerve regeneration. Over the last decade, substantial advances have been made in elucidating the underlying molecular mechanisms in Schwann cells that lead to functional nerve repair. Moreover, the field has identified situations, such as aging and chronic denervation where these mechanisms go awry, paving the way for the development of therapeutic interventions (Arthur-Farraj and Coleman, 2021; Cattin and Lloyd, 2016; Jessen and Mirsky, 2019). A recent article by Deborde et al. (2022) has demonstrated that unfortunately there is a downside to Schwann cells having such an efficient regeneration-promoting program; the promotion of tumor invasion of peripheral nerves.