中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (9): 1952-1953.doi: 10.4103/1673-5374.367844

• 观点:退行性病与再生 • 上一篇    下一篇

果蝇脊髓性肌萎缩模型的运动缺陷是由早期神经发生过程中 SMN 耗竭引起的

  

  • 出版日期:2023-09-15 发布日期:2023-03-06

Neurodevelopmental defects as a primer of neurodegeneration: lessons from spinal muscular atrophy and Huntington’s disease

Stuart J. Grice*, Ji-Long Liu*   

  1. Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK (Grice SJ, Liu JL) 
    School of Life Science and Technology, ShanghaiTech University, Shanghai, China (Liu JL) 
  • Online:2023-09-15 Published:2023-03-06
  • Contact: Stuart J. Grice, DPhil, stuartjfgrice@gmail.com; Ji-Long Liu, PhD, jilong.liu@dpag.ox.ac.uk or liujl3@shanghaitech.edu.cn.

摘要: https://orcid.org/0000-0003-2944-6076 (Stuart J. Grice) 
https://orcid.org/0000-0002-4834-8554 (Ji-Long Liu) 

Abstract: Developmental motifs in neurodegeneration: Neurodegeneration, the prominent feature of neurodegenerative disease, is characterized by the progressive and selective loss of neuronal function. As some of the pathologies caused by neurodegeneration may be irreversible, early intervention will be required for the treatments that aim to slow or halt the manifestation of these diseases. Traditionally, neurodegeneration evokes the idea of a progressive decline of brain function, which ultimately ends with the loss of cognitive, sensory, or motor ability, and the death of specific neuronal subtypes. However, it is now starting to emerge that some neurodegenerative diseases may be caused, or at least become primed, by defects that arise during neurodevelopment.