中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (1): 7-18.doi: doi: 10.4103/1673-5374.224361

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

脑损伤和神经干细胞

  

  • 收稿日期:2017-12-22 出版日期:2018-01-15 发布日期:2018-01-15

Brain injury and neural stem cells

Parker E. Ludwig1, Finosh G. Thankam1, Arun A. Patil1, 2, Andrea J. Chamczuk2, Devendra K. Agrawal1   

  1. 1 Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA
    2 Department of Neurosurgery, Creighton University School of Medicine, Omaha, NE, USA
  • Received:2017-12-22 Online:2018-01-15 Published:2018-01-15
  • Contact: Devendra K. Agrawal, Ph.D.(Biochem), Ph.D. (Med.Sciences), MBA, MS (ITM),dkagr@creighton.edu.
  • Supported by:

    This study is supported by research grants R01 HL112597, R01 HL116042, and R01 HL120659 (to DKA).

摘要:

orcid:0000-0001-5445-0013(Devendra K. Agrawal)

Abstract:

Many therapies with potential for treatment of brain injury have been investigated. Few types of cells have spurred as much interest and excitement as stem cells over the past few decades. The multipotentiality and self-renewing characteristics of stem cells confer upon them the capability to regenerate lost tissue in ischemic or degenerative conditions as well as trauma. While stem cells have not yet proven to be clinically effective in many such conditions as was once hoped, they have demonstrated some effects that could be manipulated for clinical benefit. The various types of stem cells have similar characteristics, and largely differ in terms of origin; those that have differentiated to some extent may exhibit limited capability in differentiation potential. Stem cells can aid in decreasing lesion size and improving function following brain injury.

Key words: brain injury, brain trauma, infarction, ischemia, neural stem cells, neuronal regeneration, stroke