中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (12): 2599-2605.doi: 10.4103/1673-5374.373671

• 综述:退行性病与再生 • 上一篇    下一篇

CDP胆碱促进多发性硬化髓鞘再形成:临床试验的必要性

  

  • 出版日期:2023-12-15 发布日期:2023-06-14

CDP-choline to promote remyelination in multiple sclerosis: the need for a clinical trial

Viktoria Gudi1, Paweł Grieb2, Ralf A. Linker3, Thomas Skripuletz1, *   

  1. 1Department of Neurology, Hannover Medical School, Hannover, Germany; 2Department of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland; 3Department of Neurology, University Hospital Regensburg, Regensburg, Germany
  • Online:2023-12-15 Published:2023-06-14
  • Contact: Thomas Skripuletz, MD, skripuletz.thomas@mh-hannover.de.

摘要: https://orcid.org/0000-0002-0438-2339 (Viktoria Gudi); https://orcid.org/0000-0001-8550-335X (Thomas Skripuletz)

Abstract: Multiple sclerosis is a multifactorial chronic inflammatory disease of the central nervous system that leads to demyelination and neuronal cell death, resulting in functional disability. Remyelination is the natural repair process of demyelination, but it is often incomplete or fails in multiple sclerosis. Available therapies reduce the inflammatory state and prevent clinical relapses. However, therapeutic approaches to increase myelin repair in humans are not yet available. The substance cytidine-5′-diphosphocholine, CDP-choline, is ubiquitously present in eukaryotic cells and plays a crucial role in the synthesis of cellular phospholipids. Regenerative properties have been shown in various animal models of diseases of the central nervous system. We have already shown that the compound CDP-choline improves myelin regeneration in two animal models of multiple sclerosis. However, the results from the animal models have not yet been studied in patients with multiple sclerosis. In this review, we summarise the beneficial effects of CDP-choline on biolipid metabolism and turnover with regard to inflammatory and regenerative processes. We also explain changes in phospholipid and sphingolipid homeostasis in multiple sclerosis and suggest a possible therapeutic link to CDP-choline. 

Key words: astrocytes, CDP-choline, cuprizone, microglia, multiple sclerosis, oligodendrocytes