中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (12): 2665-2666.doi: 10.4103/1673-5374.373663

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

轴突导向在成熟中枢神经系统再生中的作用

  

  • 出版日期:2023-12-15 发布日期:2023-06-14

Axon guidance in regeneration of the mature central nervous system: step by step

Julia Schaeffer#, Noemie Vilallongue#, Stephane Belin*, Homaira Nawabi*   

  1. Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, Grenoble, France
  • Online:2023-12-15 Published:2023-06-14
  • Contact: Stephane Belin, PhD, stephane.belin@inserm.fr; Homaira Nawabi, PhD, homaira.nawabi@inserm.fr.
  • Supported by:
    This work was supported by the French National Research Agency under the “Investissements d’avenir” program (ANR-17-EURE-0003) (to SB and HN). This work was also supported by ERC-St17-759089-DRIVE and NRJ Foundation to HN and ANR ANR-18-CE16-0007 to SB. JS is supported by a postdoctoral fellowship from Fondation pour la Recherche Médicale (FRM) SPF201909009106. NV is supported by a PhD extension fellowship from Fondation pour la recherche médicale (FRM) – Programme Fin de Thèse FDT202204014716.  

摘要: https://orcid.org/0000-0001-7074-6885 (Stephane Belin) 
https://orcid.org/0000-0003-3155-2783 (Homaira Nawabi) 

Abstract: Unlocking axon regeneration in the injured central nervous system: In adult mammals, central nervous system (CNS) neurons fail to regenerate after a lesion, whether it is traumatic – after spinal cord injury for example – or in the case of neurodegenerative diseases. This causes axons to degenerate and neurons to die, leading to permanent motor and/or cognitive impairment. One of the reasons behind this regeneration failure lies in the mature CNS environment, where a number of growth-inhibitory factors, at the lesion site, contributes to axon regrowth inhibition (He and Jin, 2016). In this context, removing such extrinsic factors should alleviate the growth-inhibitory barrier. Yet, surprisingly, no robust regeneration is achieved past the lesion site. These results led researchers to investigate the intrinsic regrowth properties of adult neurons themselves. Indeed, adult CNS neurons lose their capacity to grow an axon, not only because of the switch-off of developmental pro-growth programs during maturation, but also in response to the injury itself (Belin et al., 2015; He and Jin, 2016).