中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (3): 507-508.doi: 10.4103/1673-5374.380901

• 观点:退行性病与再生 • 上一篇    下一篇

多发性硬化症药物用于神经再生

  

  • 出版日期:2024-03-15 发布日期:2023-09-02

Multiple sclerosis drug repurposing for neuroregeneration

Peter Göttle, Michael Dietrich, Patrick Küry*#br#   

  1. Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany
  • Online:2024-03-15 Published:2023-09-02
  • Contact: Patrick Küry, PhD, kuery@uni-duesseldorf.de.
  • Supported by:
    The authors’ studies on Siponimod have been financially supported by Novartis (to PK). No conflicts of interest exist between Novartis and Publication of this manuscript.

摘要: https://orcid.org/0000-0002-2654-1126 (Patrick Küry)

Abstract: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS) and is primarily characterized by immune cell infiltration leading to relapses followed by remission phases and a disease course turning progressive over time with neurodegenerative processes taking over (Amin and Hersh, 2023). Of note, beyond relapse-associated worsening early in disease progression independent of relapse activity may arise independently of relapse activity and can occur in all phenotypes. Autoimmune-mediated damage of myelin sheaths and the subsequent loss of mature oligodendrocytes are resulting in impaired axonal integrity, neurodegeneration and accounts for irreversible neuronal damage (Kuhlmann et al., 2023). The current landscape of available disease-modifying therapies comprises mainly immunomodulatory drugs that effectively diminish relapses and slow down progression at the onset form of the disease, namely relapsing MS (RMS). In this regard, a number of drugs have been approved as disease-modifying therapies for MS by US Food and Drug Administration and European Medicines Agencies (Box 1).