中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (3): 571-577.doi: 10.4103/1673-5374.380877

• 综述:退行性病与再生 • 上一篇    下一篇

聚氧化钒酸盐——治疗神经退行性疾病和衰老疾病的新选择

  

  • 出版日期:2024-03-15 发布日期:2023-09-02

Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases

Sonia Irais Gonzalez-Cano1, Gonzalo Flores2, Jorge Guevara3, Julio Cesar Morales-Medina4, Samuel Treviño1, Alfonso Diaz1, *   

  1. 1Faculty of Chemical Sciences, Benemerita Autonomous University of Puebla, Puebla, Mexico; 2Institute of Physiology, Benemerita Autonomous University of Puebla, Puebla, Mexico;  3Department of Biochemistry, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico; 4Animal Reproduction Research Center, CINVESTAV- Autonomous University of Tlaxcala, Tlaxcala, Mexico
  • Online:2024-03-15 Published:2023-09-02
  • Contact: Alfonso Diaz, PhD, alfonso.diaz@correo.buap.mx.
  • Supported by:
    This work was funded by project from National Research System (CONACYT), Mexico (to SIGC). CONACYT has no role in the writing or discussion of the present review.

摘要: https://orcid.org/0000-0003-4092-6636 (Alfonso Diaz)

Abstract: Aging is a natural phenomenon characterized by a progressive decline in physiological integrity, leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases, including cardiovascular diseases, osteoporosis, cancer, diabetes, and neurodegeneration. Aging is considered the major risk factor for Parkinson’s and Alzheimer’s disease develops. Likewise, diabetes and insulin resistance constitute additional risk factors for developing neurodegenerative disorders. Currently, no treatment can effectively reverse these neurodegenerative pathologies. However, some antidiabetic drugs have opened the possibility of being used against neurodegenerative processes. In the previous framework, Vanadium species have demonstrated a notable antidiabetic effect. Our research group evaluated polyoxidovanadates such as decavanadate and metforminium-decavanadate with preventive and corrective activity on neurodegeneration in brain-specific areas from rats with metabolic syndrome. The results suggest that these polyoxidovanadates induce neuronal and cognitive restoration mechanisms. This review aims to describe the therapeutic potential of polyoxidovanadates as insulin-enhancer agents in the brain, constituting a therapeutic alternative for aging and neurodegenerative diseases.

Key words: Alzheimer’s disease, antidiabetic, brain, cognition, diabetes, insulin, neurodegeneration, neuroinflammation, oxidative stress, Vanadium species