中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (5): 957-958.doi: 10.4103/1673-5374.385298

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

溶酶体运输调节因子在神经元自噬溶酶体重组中的作用:从疾病角度

  

  • 出版日期:2024-05-15 发布日期:2023-10-31

Role of lysosomal trafficking regulator in autophagic lysosome reformation in neurons: a disease perspective

Prashant Sharma*,  Jenny Serra-Vinardell,  Wendy J. Introne,  May Christine V. Malicdan   

  1. NIH Undiagnosed Diseases Program, Common Fund, Office of the Director, National Institutes of Health, Bethesda, MD, USA (Sharma P, Malicdan MCV)
    Human Biochemical Genetics Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA (Serra-Vinardell J, Introne WJ, Malicdan MCV)
  • Online:2024-05-15 Published:2023-10-31
  • Contact: Prashant Sharma, PhD, sharmap@nih.gov.

摘要: https://orcid.org/0000-0002-1165-980X (Prashant Sharma) 

Abstract: Lysosomes are discrete organelles that act as recycling centers for extracellular and intracellular materials, playing a pivotal role in maintaining cellular homeostasis. Their acidic environment, maintained by numerous hydrolytic enzymes, facilitates substrate degradation. Dysfunction in lysosomal processes can lead to abnormal substrate degradation, significantly impacting cellular homeostasis. High energy-demanding cells, such as post-mitotic neurons, are especially vulnerable to these changes, often resulting in neurological diseases. Autophagy, a conserved catabolic process, requires extensive lysosomal utilization. It plays a key role in removing unnecessary intracellular components, ensuring cellular homeostasis, and promoting cell survival during stress conditions such as starvation, infection, or cellular damage.