中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (5): 961-962.doi: 10.4103/1673-5374.382245

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

唐氏综合征APP基因剂量对突触影响的新见解

  

  • 出版日期:2024-05-15 发布日期:2023-10-31

New insights into the effects of APP gene dose on synapse in Down syndrome

Xu-Qiao Chen*, Xinxin Zuo*   

  1. Department of Neurosciences, University of California San Diego, La Jolla, CA, USA
  • Online:2024-05-15 Published:2023-10-31
  • Contact: Xu-Qiao Chen, PhD, q0chen@ucsd.edu; Xinxin Zuo, PhD, x3zuo@ucsd.edu.

摘要: https://orcid.org/0000-0001-9799-7246 (Xu-Qiao Chen)

Abstract: Synaptic dysfunction: Alzheimer’s disease (AD) is a prevalent form of dementia, affecting over 35 million people worldwide (Tzioras et al., 2023). A synapse serves as the connection point between neurons, facilitating the transmission of information from one neuron to another. Dynamic alterations in synapses, known as synaptic plasticity, play a pivotal role in cognitive processes such as learning and memory. Synaptic loss has been identified as a key contributor to cognitive decline in AD patients. Studies have shown that the soluble forms of amyloid-beta (Aβ) and tau proteins are toxic to synapses, leading to cognitive impairment in animal models (Spires-Jones and Hyman, 2014). Additionally, the formation of oligomers of tau and Aβ can spread pathology through synaptic connections in the brain, emphasizing the vital role of synapses in disease progression.