中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (on line): 1-8.

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Oligodendrocytes in central nervous system diseases: the effect of cytokine regulation

  

  • 出版日期:2024-01-01 发布日期:2023-11-25

Chengfu Zhang1, 2, Mengsheng Qiu3, Hui Fu4, *   

  1. 1Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China; 2Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China; 3Institute of Life Sciences, Key Laboratory of Organ Development and Regeneration of Zhejiang Province, College of Life and Environment Sciences, Hangzhou Normal University, Hangzhou, Zhejiang Province, China; 4Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, Zhejiang Province, China
  • Online:2024-01-01 Published:2023-11-25
  • Contact: Hui Fu, PhD, hueyfu@hotmail.com.
  • Supported by:
    This work was supported by the Natural Science Foundation of Zhejiang Province, No. LQ23C090003 (to CZ); The Major Project on Brain Science and Analog Brain Research of Ministry of Science and Technology of China, No. 2022ZD0204701 (to MQ), and the National Natural Science Foundation of China, No. 32170969 (to MQ).

摘要: https://orcid.org/0000-0003-0252-6009 (Hui Fu)

Abstract: Cytokines, including tumor necrosis factor, interleukins, interferons, and chemokines, are abundantly produced in various diseases. As pleiotropic factors, cytokines are involved in nearly every aspect of cellular functions, such as migration, survival, proliferation, and differentiation. Oligodendrocytes are the myelin-forming cells in the central nervous system and play critical roles in the conduction of action potentials, the supply of metabolic components for axons, and other functions. Emerging evidence suggests that both oligodendrocytes and oligodendrocyte precursor cells are vulnerable to cytokines released under pathological conditions. This review mainly summarizes the effects of cytokines on oligodendrocyte lineage cells in central nervous system diseases. A comprehensive understanding of the effects of cytokines on oligodendrocyte lineage cells contributes to our understanding of central nervous system diseases and offers insights into treatment strategies.

Key words: central nervous system disease, CXC chemokine, cytokine, interferon γ, interleukin, microglia, astrocyte, oligodendrocyte precursor cell, oligodendrocyte, tumor necrosis factor α