中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (7): 1397-1398.doi: 10.4103/1673-5374.387981

• 观点:神经损伤修复保护与再生 •    下一篇

内质网与小胶质细胞:作用新见解

  

  • 出版日期:2024-07-15 发布日期:2023-11-28

New insights into the role of the endoplasmic reticulum in microglia

Veronika E. Neubrand, M. Rosario Sepúlveda#br#   

  1. Department of Cell Biology, Faculty of Sciences, University of Granada, Granada, Spain
  • Online:2024-07-15 Published:2023-11-28
  • Contact: M. Rosario Sepúlveda, PhD, mrsepulveda@ugr.es.
  • Supported by:
    This work was funded by grants PPJIA2022.29 (to VEN) and PP2022.PP.29 (to MRS) from University of Granada Research Program, Spain. 

摘要: https://orcid.org/0000-0002-2375-5866 (M. Rosario Sepúlveda)

Abstract: Microglial cells are the only resident immune cells in the central nervous system and constitute its frontline guardian. They are extremely reactive against infections, trauma, or toxins, but are also responsible for mediating inflammation, taking part in the pathogenic course of many neuropathologies (Sierra et al., 2019). Cell-specific staining, ultrastructural analysis by transmission electron microscopy (TEM), or two-photon-microscopy imaging have been relevant for the characterization of microglia as well as their cell-cell interactions, which have led to a better understanding of microglial roles in health and disease.