中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (8): 1633-1634.doi: 10.4103/1673-5374.389632

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

利用小胶质细胞源性细胞外囊泡捕捉神经损伤后小胶质细胞活化表型的多样性

  

  • 出版日期:2024-08-15 发布日期:2024-01-03

Using microglia-derived extracellular vesicles to capture diversity of microglial activation phenotypes following neurological injury

Austyn D. Roseborough, Nikita Ollen-Bittle, Shawn N. Whitehead*#br#   

  1. Vulnerable Brain Laboratory, Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, London, OH, Canada
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Shawn N. Whitehead, PhD, shawn.whitehead@schulich.uwo.ca.

摘要: https://orcid.org/0000-0003-4728-8067 (Shawn N. Whitehead)

Abstract: Microglia are one of the three glial cell populations in the central nervous system (CNS), along with astrocytes and oligodendrocytes. While microglia are unique among brain cells due to their hematologic origin and perform immune functions similar to peripheral macrophages, they are not simply macrophages of the CNS. Microglia are crucial for many brain-specific functions such as synaptic pruning, facilitation of myelin turnover and communication with both neurons and astrocytes (Saijo and Glass, 2011). They are a highly active cell type, constantly surveying their environment and responding to both exogenous and endogenous danger signals which can include reactive oxygen species, cytosolic DNA, heat shock proteins, plasma proteins and microbial components.