中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (8): 1637-1638.doi: 10.4103/1673-5374.389638

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

糖酵解和葡萄糖代谢作为青光眼生物能量和神经元保护的靶点

  

  • 出版日期:2024-08-15 发布日期:2024-01-03

Glycolysis and glucose metabolism as a target for bioenergetic and neuronal protection in glaucoma

Pete A. Williams*, Robert J. Casson   

  1. Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden (Williams PA) 
    Ophthalmic Research Laboratories, Discipline of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, Australia (Casson RJ)
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Pete A. Williams, PhD, pete.williams@ki.se.
  • Supported by:
    This work was supported by Karolinska Institutet in the form of a Board of Research Faculty Funded Career Position, by St. Erik Eye Hospital philanthropic donations, and Vetenskapsrådet 2022-00799 (to PAW). PAW is an Alcon Research Institute Young Investigator.

摘要: https://orcid.org/0000-0001-6194-8397 (Pete A. Williams)

Abstract: Vision is arguably our most valued sense, yet approximately 340 million people globally suffer blindness or moderate visual impairment, highlighting the need to further develop and advance treatments for ophthalmic diseases. Glaucoma refers to a group of ocular disorders united by a clinically characteristic optic neuropathy with associated retinal ganglion cell loss. It is one of the most prevalent neurodegenerations globally, the leading cause of irreversible blindness, and affects ~80 million people worldwide (with an estimated further 40 million undiagnosed).