中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (on line): 1-12.

• •    下一篇

Persistent gray matter alterations in COVID-19 patients with sleep disturbances: a 3-month longitudinal study

  

  • 出版日期:2024-01-01 发布日期:2024-03-13

Kaixuan Zhou1, 2, #, Gaoxiong Duan2, #, Ying Liu2, Bei Peng2, Xiaoyan Zhou2, Lixia Qin3, Lingyan Liang2, Yichen Wei2, Qingping Zhang2, Xiaocheng Li2, Haixia Qin2, Yinqi Lai2, Yian Lu3, Yan Zhang2, Jiazhu Huang2, Jinli Huang2, Yinfei Ouyang2, Bolin Bin2, Mingming Zhao3, Jun Liu4, *, Jianrong Yang5, *, Demao Deng1, 2, *   

  1. 1School of Medicine, Guangxi University, Nanning, Guangxi Zhuang Autonomous Region, China; 2Department of Radiology, the People’s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region, China; 3Department of Sleep Medicine, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region, China; 4Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China; 5Guangxi Clinical Reserch Center for Sleep Medicine, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning Guangxi Zhuang Autonomous Region, China
  • Online:2024-01-01 Published:2024-03-13
  • Contact: Demao Deng, MD, demaodeng@163.com; Jianrong Yang, MBBS, gandansurgery2014@163.com; Jun Liu, MD, junliu123@csu.edu.cn.
  • Supported by:
    This work was supported by grants from Major Project of Science and Technology of Guangxi Zhuang Autonomous Region, No. Guike-AA22096018 (to JY), Guangxi Key Research and Development Program, No. AB22080053 (to DD), Major Project of Science and Technology of Guangxi Zhuang Autonomous Region, No. Guike-AA23023004 (to MZ), the National Natural Science Foundation of China, Nos. 82260021 (to MZ), 82060315 (to DD), Natural Science Foundation of Guangxi, No. 2021GXNSFBA220007 (to GD), Clinical Research Center For Medical Imaging In Hunan Province, No. 2020SK4001 (to JL), Key Emergency Project of Pneumonia Epidemic of novel coronavirus infection in Hunan Province, No. 2020SK3006 (to JL), and science and technology innovation program of Hunan Province, No. 2021RC4016 (to JL).

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摘要： https://orcid.org/0000-0002-7565-2607 (Demao Deng)

Abstract: Sleep disturbances (SD) are among the most frequent neuropsychiatric manifestations in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Previous studies showed abnormal brain structures in patients with SD who had recovered from coronavirus disease 2019 (COVID-19) after 2 years of follow-up. Thus far, however, neuroimaging studies of SD caused by COVID-19 are scarce and have mainly focused on the post-COVID-19 condition, lacking acute phase data and leading to a limited understanding of the pathophysiology of SD. Therefore, we designed a longitudinal study to explore whether alterations in brain structure occur in the acute phase of infection and verified the results by using 3-month follow-up data. A total of 26 COVID-19 patients with SD, 27 COVID-19 patients without SD (NSD), and 31 matched healthy controls underwent structural magnetic resonance imaging scanning, blood sampling and Pittsburgh Sleep Quality Index (PSQI) evaluations. Eleven SD patients were asked to return after 3 months, enabling a longitudinal analysis. We focused on alterations in cortical thickness, cortical gray matter volume, cortical surface area, and subcortical volume and their relationships with PSQI scores. We found that the COVID-19 patients with SD had brain structural changes in almost all brain lobes. The cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with PSQI scores. We also found changes in the volume of the hippocampus and its subfield regions in COVID-19 patients relative to the healthy controls. Furthermore, the 3-month follow-up longitudinal results revealed altered cerebral structure indices (cortical thickness, cortical grey matter volume, and cortical surface area) in the frontal–parietal cortex compared with the baseline in COVID-19 patients with SD. Our findings revealed altered morphology in the cortical and hippocampal structures in the acute phase of infection and persistent changes in cortical regions at the 3-month follow-up in SD patients, filling in the knowledge gaps for acute-phase evidence and enabling a better understanding of the pathophysiology of the SD caused by COVID-19.

Key words: sleep disturbances, SARS-CoV-2, COVID-19, cortical thickness, cortical gray matter volume, cortical surface area, sub-cortical volume, hippocampus, magnetic resonance imaging, brain structure