中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (12): 2561-2562.doi: 10.4103/NRR.NRR-D-23-01123

• 观点:退行性病与再生 • 上一篇    下一篇

肥胖大脑的结构变化

  

  • 出版日期:2024-12-15 发布日期:2024-03-30

Structural changes in the obese brain

Anna R.R. Da Conceicao#, Marcelo N.N. Vieira#, Fernanda G. De Felice*#br#   

  1. D’Or Institute for Research and Education, Rio de Janeiro, Brazil (Da Conceicao ARR, Vieira MNN, 
    De Felice FG)
    Institute of Medical Biochemistry Leopoldo De Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil (Da Conceicao ARR, De Felice FG) 
    Centre for Neuroscience Studies, Department of Biomedical and Molecular Sciences & Department of Psychiatry, Queen’s University, Kingston, ON, Canada (De Felice FG)
  • Online:2024-12-15 Published:2024-03-30
  • Contact: Fernanda G. De Felice, PhD, fernanda.defelice@queensu.ca.

摘要: https://orcid.org/0000-0001-8358-0589 (Fernanda G. De Felice)

Abstract: Obesity represents a major global health concern, with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare systems (Prospective Studies Collaboration, 2009). Obesity is a well-established risk factor for a variety of conditions including metabolic, vascular, and heart diseases, and several types of cancer (Prospective Studies Collaboration, 2009). In addition, in the past few decades, accumulating clinical and epidemiological evidence associates obesity with cognitive decline and a higher risk for developing neurodegenerative and neuropsychiatric disorders such as Alzheimer’s disease (AD), anxiety, and depression. A recent large-scale cross-sectional study concluded that midlife obesity is now the most prominent modifiable risk factor for developing AD and related dementia in the US (Nianogo et al., 2022). Further evidence from a prospective study with 1 million UK women (mean age of 56 years at baseline) shows that a body mass index (the anthropometric marker for obesity) > 30 kg/m2 at baseline was associated with a higher incidence of dementia 15 years later (Floud et al., 2018).