中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (12): 2673-2683.doi: 10.4103/NRR.NRR-D-23-01031

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

NG2 在神经创伤中的神经源潜力

  

  • 出版日期:2024-12-15 发布日期:2024-03-30

Neurogenic potential of NG2 in neurotrauma: a systematic review#br#

Yuri R. Rigo1, Radharani Benvenutti2, Luis V. Portela1, Nathan R. Strogulski3, *   

  1. 1Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; 2School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland; 3School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin, Ireland
  • Online:2024-12-15 Published:2024-03-30
  • Contact: Nathan R. Strogulski, PhD, n.strogulski@gmail.com.
  • Supported by:
    This work was supported by funding from FAPERGS under Grant No. 1010267; FAPERGS/PPSUS, No. 17/2551-0001; FAPERGS/PRONEX, No. 16/2551-0000499-4; FAPERGS/CAPES under Grant No. 19/25510000717-5; Conselho Nacional de Desenvolvimento Científico e Tecnológico under Grants Nos. 4011645/2012-6 and #5465346/2014-6; Irish Research Council Government of Ireland Postdoctoral Fellowship, No. GOIPD/2022/792; and Irish Research Council Enterprise Postdoctoral Fellowship, No. EPSPD/2022/112.

摘要: https://orcid.org/0000-0003-2166-2137 (Nathan R. Strogulski)

Abstract: Regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of research. This is reflected in a large disparity between the number of studies investigating primary and secondary injury as therapeutic targets in spinal cord and traumatic brain injuries. Significant advances in biotechnology may have the potential to reshape the current state-of-the-art and bring focus to primary injury neurotrauma research. Recent studies using neural-glial factor/antigen 2 (NG2) cells indicate that they may differentiate into neurons even in the developed brain. As these cells show great potential to play a regenerative role, studies have been conducted to test various manipulations in neurotrauma models aimed at eliciting a neurogenic response from them. In the present study, we systematically reviewed the experimental protocols and findings described in the scientific literature, which were peer-reviewed original research articles (1) describing preclinical experimental studies, (2) investigating NG2 cells, (3) associated with neurogenesis and neurotrauma, and (4) in vitro and/or in vivo, available in PubMed/MEDLINE, Web of Science or SCOPUS, from 1998 to 2022. Here, we have reviewed a total of 1504 papers, and summarized findings that ultimately suggest that NG2 cells possess an inducible neurogenic potential in animal models and in vitro. We also discriminate findings of NG2 neurogenesis promoted by different pharmacological and genetic approaches over functional and biochemical outcomes of traumatic brain injury and spinal cord injury models, and provide mounting evidence for the potential benefits of manipulated NG2 cell ex vivo transplantation in primary injury treatment. These findings indicate the feasibility of NG2 cell neurogenesis strategies and add new players in the development of therapeutic alternatives for neurotrauma.

Key words: neural-glial antigen 2, neural-glial factor 2, neuron differentiation, NG2 cell, regeneration, spinal cord injury (SCI), traumatic brain injury (TBI)