中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (1): 107-115.doi: 10.4103/NRR.NRR-D-23-01964

• 综述:退行性病与再生 • 上一篇    下一篇

中枢神经系统中的高迁移率组盒1:隐藏在炎症之下的再生

  

  • 出版日期:2025-01-15 发布日期:2025-01-15

High mobility group box 1 in the central nervous system: regeneration hidden beneath inflammation

Hanki Kim1, 2, Bum Jun Kim1, 2, Seungyon Koh1, 2, 3, Hyo Jin Cho1, Xuelian Jin1, 4, Byung Gon Kim1, 3, Jun Young Choi1, 3, *   

  1. 1Department of Brain Science, Ajou University School of Medicine, Suwon, South Korea; 2Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, South Korea; 3Department of Neurology, Ajou University School of Medicine, Suwon, South Korea; 4Department of Geriatrics, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian, Jiangsu Province, China
  • Online:2025-01-15 Published:2025-01-15
  • Contact: Jun Young Choi, MD, PhD, taz312@gmail.com or jychoi@aumc.ac.kr.
  • Supported by:
    This work was supported by a grant of the M.D.-Ph.D./Medical Scientist Training Program through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (to HK). This work was also supported by National Research Foundation of Korea (NRF) grants funded by the Korean government (MSIT; Ministry of Science and ICT) (NRF2019R1A5A2026045 and NRF-2021R1F1A1061819); a grant from the Korean Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HR21C1003); and New Faculty Research Fund of Ajou University School of Medicine (to JYC).

摘要: https://orcid.org/0000-0002-6031-3549 (Jun Young Choi) 

Abstract: High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields, including neurology and neuroscience. High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern, which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke, Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease, multiple sclerosis, epilepsy, and traumatic brain injury. Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern, such as glycyrrhizin, ethyl pyruvate, and neutralizing anti-high-mobility group box 1 antibodies, are commonly used to target high-mobility group box 1 activity in central nervous system disorders. Although it is commonly known for its detrimental inflammatory effect, high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders. In this narrative review, we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern, its downstream receptors, and intracellular signaling pathways, how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system, and clues on how to differentiate the pro-regenerative from the pro-inflammatory role. Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

Key words: central nervous system, damage-associated molecular pattern, ethyl pyruvate, glycyrhizzin, high mobility group box 1, inflammation, neural stem cells, neurodevelopment, oligodendrocyte progenitor cells, redox status, regeneration