中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (1): 181-183.doi: 10.4103/NRR.NRR-D-23-01967

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

间充质干细胞的分泌组会影响脊髓感觉回路吗?疼痛疗法的意义

  

  • 出版日期:2025-01-15 发布日期:2025-01-15

Does mesenchymal stem cell’s secretome affect spinal sensory circuits? Implication for pain therapies

Francesco Ferrini, Esri H. Juárez, Adalberto Merighi   

  1. Department of Veterinary Sciences, University of Turin, Grugliasco, TO, Italy (Ferrini F, Juárez EH, Merighi A)  Department of Psychiatry and Neuroscience, Université Laval, Québec City, QC, Canada (Ferrini F)
  • Online:2025-01-15 Published:2025-01-15
  • Contact: Adalberto Merighi, PhD, adalberto.merighi@unito.it.
  • Supported by:
    This work was supported by the National Centre for the Replacement Refinement & Reduction of Animals in Research Crack It solution “Neuroinflammation and nociception in a dish” (https://nc3rs.org.uk/crackit/news/new-solution-neuroinflammation-and-nociception-dish) fund (to AM).

摘要: https://orcid.org/0000-0002-1140-3556 (Adalberto Merighi) 

Abstract: Mesenchymal stem cells (MSCs) are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues, including bone marrow, tooth pulp, adipose tissue, and umbilical cord. MSCs have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue repair. MSCs enrich the medium in which they are cultivated with a broad range of bioactive molecules, including growth factors, cytokines, chemokines, enzymes, nucleic acids, and extracellular vesicles that collectively compose the MSC secretome. An increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium (i.e., the medium collected from MSC cultures after at least 3 days of exposure) exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions, including chronic pain. Importantly, since therapies based on MSC transplantation are highly impaired by the limited cell survival in the host and by the potential occurrence of immunological adverse responses, MSC secretome represents a safer and more viable alternative to these therapies.