中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (1): 191-192.doi: 10.4103/NRR.NRR-D-23-01843

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

血管内皮生长因子:白质病变发展中的一把双刃剑

  


  • 出版日期:2025-01-15 发布日期:2025-01-15

Vascular endothelial growth factor: a double-edged sword in the development of white matter lesions

Narek Manukjan, Daniel Fulton, Zubair Ahmed*, W. Matthijs Blankesteijn, Sébastien Foulquier*   

  1. Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands (Manukjan N, Blankesteijn WM, Foulquier S)
    CARIM - School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands (Manukjan N, Blankesteijn WM, Foulquier S)
    Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham, UK (Manukjan N, Fulton D, Ahmed Z)
    Centre for Trauma Sciences Research, University of Birmingham, Edgbaston, Birmingham, UK (Fulton D, Ahmed Z)
    MHeNs—School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands (Foulquier S)
    Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands (Foulquier S)
  • Online:2025-01-15 Published:2025-01-15
  • Contact: Sébastien Foulquier, PhD, sebastien.foulquier@maastrichtuniversity.nl; Zubair Ahmed, PhD, z.ahmed.1@bham.ac.uk.

摘要: https://orcid.org/0000-0002-2523-0748 (Sébastien Foulquier)
https://orcid.org/0000-0001-6267-6442 (Zubair Ahmed) 

Abstract: As the population ages, the burden of age-related diseases becomes greater. Currently, over 55 million people suffer from dementia worldwide, with Alzheimer’s disease being the most common form. However, it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease (cSVD) may be a more detrimental cause for dementia (Cuadrado-Godia et al., 2018). It is estimated that 10%–30% of the elderly population and 35%–90% of all dementia patients exhibit signs of cSVD. The term cSVD refers to pathology affecting the small vessels of the brain, which can lead to lacunar cerebral infarcts, enlarged perivascular spaces, and cortical hemorrhages (Cuadrado-Godia et al., 2018). CSVD is often associated with cognitive decline, gait problems, and dementia (Cuadrado-Godia et al., 2018). To minimize disease progression, preventive measures, and early interventions, such as risk factor management, are crucial. However, due to its asymptomatic nature, the disease is often silent and diagnosed coincidentally at later stages. Thus, the window of opportunity for prevention and treatment is often missed.