中国神经再生研究(英文版) ›› 2024, Vol. 20 ›› Issue (2): 481-482.doi: 10.4103/NRR.NRR-D-23-02059

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

生物电子医学在调节皮层扩散去极化及其他方面的作用

  

  • 出版日期:2025-02-15 发布日期:2024-06-18

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

Khaled Alok#, Timothy G. White#, Chunyan Li*   

  1. Department of Neurosurgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA (Alok K, White TG, Li C)
    Translational Brain Research Laboratory, The Feinstein Institutes for Medical Research, Manhasset, NY, USA (Li C)
  • Online:2025-02-15 Published:2024-06-18
  • Contact: Chunyan Li, PhD,cli11@northwell.edu.
  • Supported by:
    This article was supported by National Institute of Neurological Disorders and Stroke of the National Institutes of Health under award number R21NS114763, US Army Medical Research and Materiel Command (USAMRMC) under award # W81XWH-18-1-0773, and merit-based career enhancement award at the Feinstein Institutes for Medical Research (to CL).

摘要: https://orcid.org/0000-0001-5169-3976 (Chunyan Li)

Abstract: Bioelectronic interventions, specifically trigeminal nerve stimulation (TNS), have attracted considerable attention in conditions where cortical spreading depolarizations (CSDs) accompanied by compromised cerebral perfusion may exacerbate neurological damage. While pharmacological interventions have demonstrated initial potential in addressing CSDs, a standardized treatment approach has not yet been established. The objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs, particularly emphasizing TNS, and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.