中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (3): 417-418.doi: 10.4103/1673-5374.228719

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

代谢、神经变性和表观遗传学中 sirtuins的新角色

  

  • 收稿日期:2018-02-01 出版日期:2018-03-15 发布日期:2018-03-15

Metabolism, neurodegeneration and epigenetics: emerging role of Sirtuins

Dafne M. Silberman   

  1. Centro de Estudios Farmacológicos y Botánicos (CEFYBO-UBACONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
  • Received:2018-02-01 Online:2018-03-15 Published:2018-03-15
  • Contact: Dafne M. Silberman, Ph.D.,dsilberman@fmed.uba.ar

摘要:

orcid: 0000-0002-1698-7191 (Dafne M. Silberman)

Abstract:

Along with the progressive aging of the population, the prevalence of obesity, metabolic diseases and neurodegenerative disorders continues to grow. Moreover, increasing evidence suggests that metabolic alterations strongly influence the initiation and progression of neurodegenerative disorders. Accordingly, brain aging is accompanied by metabolic, morphological and neurophysiological changes leading to the development of neurodegenerative diseases like Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and multiple sclerosis (Procaccini et al., 2016). Since each of these disorders involve impaired energy metabolism and/or adverse changes in the cerebral vasculature, a reduction in energy availability to neurons may contribute to increased vulnerability of the brain to develop neurodegenerative processes (Camandola and Mattson, 2017).