中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (3): 797-798.doi: 10.4103/NRR.NRR-D-24-00180

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

损伤/缺血诱导的干细胞:神经再生的最新知识和未来展望

  

  • 出版日期:2025-03-15 发布日期:2024-06-26

Injury/ischemia-induced stem cells: up-to-date knowledge and future perspectives for neural regeneration

Takayuki Nakagomi*   

  1. Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Japan 
    Department of Therapeutic Progress in Brain Diseases, Hyogo Medical University, Nishinomiya, Japan
  • Online:2025-03-15 Published:2024-06-26
  • Contact: Takayuki Nakagomi, MD, PhD, nakagomi@hyo-med.ac.jp.
  • Supported by:
    The Department of Therapeutic Progress in Brain Diseases is financially supported by Nippon Zoki Pharmaceutical Co., Ltd. No direct conflicts of interest exist between Nippon Zoki Pharmaceutical Co., Ltd. and the publication of this article.

摘要: https://orcid.org/0000-0003-2274-410X (Takayuki Nakagomi)

Abstract: Brain injuries like ischemic stroke induce endogenous stem cell production. Although the precise traits of stem cells in pathological brains remain unclear, we previously demonstrated that injury/ischemia-induced stem cells (iSCs) are present in the post-stroke mouse (Nakagomi et al., 2009) and human brains (Beppu et al., 2019). Additionally, we demonstrated that not only mouse-derived (Nakagomi et al., 2009) but also human-derived iSCs (Beppu et al., 2019) produce electrophysiological functional neurons in vitro. Further, we recently demonstrated that transplantation of human-derived iSCs into poststroke mice improves neurological function, presumably by neural replacement and the formation of neural networks with endogenous neurons (Nakagomi et al., 2023). Thus, iSCs may play an important role in neural regeneration after brain injuries, such as ischemic stroke. Herein, we introduce the concept, origin, traits, and roles of iSCs and their future perspectives based on our recent findings.